09/02/2014

Gerresheimer - glass and plastic syringe systems at “PDA Universe of Pre-filled Syringes”

Gerresheimer will be presenting glass and plastic syringe systems to an expert public on Stand 512 at “PDA The Universe of Prefilled Syringes and Injection Devices“ (Hyatt Regency, Huntington Beach, California) on October 6 and 7, 2014.

Increasingly complex and varied demands made by the healthcare market - especially physicians and patients - on the pharmaceutical and healthcare industries has driven up demand for different syringe systems. The Gerresheimer Group offers a comprehensive and innovative portfolio of pharmaceutical primary packaging products and is one of the leading experts in the development and manufacture of syringes made from glass and cyclic olefins.

Baked-on Gx RTF 1ml long and Gx TELC - the ideal combination for ophthalmic applications

The inside of ready-to-fill glass syringes is treated with silicone oil to ensure smooth plunger movement and even discharge of syringe content. However, this is associated with the disadvantage that the silicone oil forms fine droplets in the syringe’s content. Although these droplets are entirely harmless to the patient when injected, they do in rare cases interact with the medical preparation.

Gerresheimer‘s baked-on Gx RTF syringe is a pre-fillable syringe with significantly less silicone oil than other syringes. In a patented process, a silicone oil emulsion is applied to the inside surface of the syringe and then baked on to the syringe wall. It provides excellent glide properties and considerably reduces the quantity of silicone oil particles, which makes this syringe ideal for ophthalmic applications.

In conjunction with the Gx TELC (Tamper Evident Luerlock Closure), which is securely mounted on the syringe, this ready-to-fill syringe is perfectly suited to ophthalmic surgery applications. Luer lock adapters allow the user to screw finer needles into the syringe if necessary. The closure has another safety feature in addition to its extremely tight fit: an indicator which cannot be returned to its original position once the syringe has been opened, so that the medical personnel immediately knows whether it has been used or not.

The ophthalmic syringe also has a back stop to ensure that the plunger head cannot be pulled out of the syringe, keeping the medication safe inside. The back stop gives the syringe additional ergonomic handling properties which are an advantage in high precision ophthalmic surgery.

ClearJect 1 ml long version available

Ready-to-fill syringes are manufactured in both glass and COP. The Gerresheimer product portfolio of ready-to-fill syringes for the pharmaceutical sector now also includes the proven ClearJect COP syringes by Taisei Kako Co. Ltd. Gerresheimer is responsible for technical customer services and the marketing of ClearJect TasPack syringe systems in Europe and America.

The ClearJect syringe with needle is available in 0.5 ml, 1 ml, 2.25 ml and 5 ml Luer cone and Luer lock versions, as well as a 1 ml long version. It has a rigid needle shield protecting a 27 gauge, ½ inch needle.

The ClearJect syringes are injection molded. The 1 ml long syringe with needle differs from a glass syringe in that it doesn’t have a glued-in needle. The plastic is actually molded around the needle in the injection molding process, so ClearJect needle tips are adhesive free. Another difference between glass syringe and COP syringe production processes is that the COP syringe has no tungsten pin. As a result, the 1 ml WN (With Needle) syringes by Taisei are particularly suitable for sensitive drug formulations that interact with tungsten.

The ClearJect syringes also satisfy Japanese quality requirements. They are available in ready-to-use format under the TasPack (Taisei Kako Advanced Sterile Packaging) brand name. Customer-specific formats can also be manufactured if required.

COP is highly shock-resistant and breakproof. It also has glass-like transparency with high barrier properties against water vapor and oxygen. Syringes made of COP are therefore perfect as a primary packaging for the sensitive pharmaceutical drugs used in oncology, ophthalmology and other fields of medicine.

Like glass syringes, ClearJect TasPack syringes are packaged and marketed as ready-to-use systems. The rubber components in the ClearJect system (plunger heads and tip caps) conform to current requirements of modern pharmaceutical elastomers and are made of latex-free chlorobutyl.

Source: Gerresheimer/gerresheimer.com